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Official Publication of the Indian Association for the Study of Sexually Transmitted Disesses
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ORIGINAL ARTICLE
Year : 2008  |  Volume : 29  |  Issue : 2  |  Page : 86-88

Lipodystrophy among AIDS patients: A preliminary report


1 Madurai Medical College and Government Rajaji Hospital, Madurai - 625 020, India
2 Emeritus Professor of Internal Medicine The Tamilnadu Dr. MGR Medical University, Chennai, India

Correspondence Address:
M Srinivasan
136, Second East Main Road, Anna Nagar, Madurai - 625 020, Tamil Nadu
India
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DOI: 10.4103/0253-7184.48731

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Background : Lipodystrophy (LD) is potentially stigmatizing and contributes to poor adherence to ­antiretroviral therapy. Objectives : To find out the prevalence and pattern of LD among Acquired Immune Deficiency ­ Syndrome (AIDS) patients receiving Highly Active Antiretroviral Therapy (HAART), and to assess the ­psychological distress related to LD. Materials and methods : A cross-sectional study was designed after institutional ethical clearance and informed consent from 50 AIDS patients on HAART. Data collected were physical examination and response to a standardized questionnaire (Assessment of Body Changes and Distress questionnaire). They were analyzed using SPSS 14.0. Results : All subjects were on lamivudine, stavudine, and nevirapine (82%) or efavirenz (18%). The prevalence of LD was 28% (M = 5; F = 9) and ­significantly more among women ( P = 0.019). The pattern of LD perceived by patients and assessed on physical examination were abdominal obesity in 50 and 38%, breast hypertrophy in 28 and 14%, wasting of buttocks in 22 and 26%, lipoatrophy of arms in 24 and 28%, and wasting of facial muscles in 20 and 32%, respectively. The overall perceived changes were 68%, while assessed were 62%. The body changes caused significant psychological distress to the patients ( P = 0.001), although compliance was good. Conclusion : The study calls for early detection of LD and treatment or provision of alternative medicines and counseling of these patients, to reduce the physical and psychological burden.


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