Indian J Sex Transm Dis Indian J Sex Transm Dis
Official Publication of the Indian Association for the Study of Sexually Transmitted Disesses
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LETTER TO EDITOR
Year : 2009  |  Volume : 30  |  Issue : 2  |  Page : 121
 

Aminotransferase profile in HIV positive patients


Flat no 6, Prasanna Apartments, 912 Shivajinagar, Pune 411004, Maharashtra, India

Date of Web Publication24-Apr-2010

Correspondence Address:
Ivan Netto
Dr. Ranjit Patil, Flat no 6, Prasanna Apartments, 912 Shivajinagar, Pune 411004, Maharashtra
India
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DOI: 10.4103/0253-7184.62772

PMID: 21938136

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How to cite this article:
Netto I, Borgaonkar K, Lobo R. Aminotransferase profile in HIV positive patients. Indian J Sex Transm Dis 2009;30:121

How to cite this URL:
Netto I, Borgaonkar K, Lobo R. Aminotransferase profile in HIV positive patients. Indian J Sex Transm Dis [serial online] 2009 [cited 2014 Sep 30];30:121. Available from: http://www.ijstd.org/text.asp?2009/30/2/121/62772


Sir,

As known, the liver is a major part of reticuloendothelial system and is a site of HIV replication and organ for many opportunistic infections. In HIV infected individuals, abnormal biochemical test results can develop as a result of hepatic parenchymal disease. The transaminases (alanine aminotransferase and aspartate aminotransferase) are enzymes made in liver. When liver cells are damaged these enzymes leak into bloodstream. Serum transaminase levels (AST and ALT) were studied for 40 HIV positive and 40 healthy and HIV negative control cases (from Government Medical College and Hospital, Aurangabad, Maharashtra, India) with mean age of approximately 35 years. Hepatomegaly cases were excluded. The mean serum AST and ALT in control group was demonstrated to be 22.15 2.67 IU/L and 17.85 1.84 IU/L, which was found to be increased up to 95.85 26.9 IU/L (p < 0.001) and 85.67 28.56 IU/L (p < 0.001) in HIV positive patients. The increase was found to be statistically highly significant. Increased levels were demonstrated in HIV patients by Vazmediano et al and Von Appen et al. [2],[3] Poles et al. stated that up to 90% of patients with AIDS had abnormalities of the liver-associated enzymes. [1] It could be concluded that the liver function tests are deranged in HIV positive patients as compared to control. The deranged serum AST and ALT levels may identify patients requiring further investigations, thus can be used as a diagnostic and prognostic tool.

 
   References Top

1.Poles MA, Lew EA, Dieterich DT. Diagnosis and treatment of hepatic disease in patients with HIV. Gastroenterol Clin North Am 1997;26:291-321.   Back to cited text no. 1  [PUBMED]    
2.Vozmediano JM, Manrique A, Petraglia S, Romero MA, Nieto I. Giant molluscum contagiosum in AIDS. Int J Dermatol 1996;35:45-7.   Back to cited text no. 2  [PUBMED]    
3.Von Appen K, Beuers U, Mόhlhφfer A, Weiss M, Thoenes GH, Samtleben W. Chronic HIV- and chronic HBV infection with hematuria and proteinuria. Dtsch Med Wochenschr 1998;123:185-8.  Back to cited text no. 3      




 

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