LETTER TO EDITOR
|Year : 2007 | Volume
| Issue : 2 | Page : 113
Prevalence of HIV-2 infection in south Tamil Nadu
S Murugan, R Anburajan
Peace HIV Care Center, Tirunelveli, Tamilnadu, India
Peace HIV Care Center, 7/A1, Railwaystation road, Palayamkottai, Tirunelveli, Tamil Nadu
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Murugan S, Anburajan R. Prevalence of HIV-2 infection in south Tamil Nadu. Indian J Sex Transm Dis 2007;28:113
The prevalence rate of HIV-2 infection in India is not available so far. Even though the HIV-1 infection is abundantly found, HIV-2 infection is also detected sporadically now and then. We undertook a study in two voluntarily counseling and testing centers (During July 2003-June 2006) to find the incidence of HIV-2 infection in and around Tirunelveli district of South Tamilnadu.
Out of 6407 tested, 18 were found to have HIV-2 infection [Table - 1]. Among these 18, only four were exclusively HIV-2 infected whereas the other 14 were having both HIV-1 and -2 infections together and these 14 had highly promiscuous activity at different parts of the country. Solomon et al. of YRG care observed an incidence of 0.8% of HIV-2 among urban population and 0.3% among rural population. 
Knowing this incidence is epidemiologically significant. HIV-2 infection is less infectious in the early course of the disease. , Vertical transmission is also rare. More number of discordant couples are come across with HIV-2 infection when compared to HIV-1 infection. In our study, we found that HIV-2 infection affected two children whereas 12 children escaped from the infection and observed six discordant couples. Moreover, non-nucleoside reverse transcriptase inhibitor (NNRTI) has no role in the management of HIV-2 infection. Nevirapine prophylaxis in prevention of mother to child transmission of HIV-2 infection also would be ineffective.
So it is high time to assess the exact incidence HIV-2 infection and to frame the special guidelines to manage HIV-2 infection and different regimen for the prevention of mother to child transmission. otherwise we will have to face serious resistant strains of HIV-2 which will possibly pose a problem in our country in future as the present regimen given in Government ART center amounts to two effective drugs only and not exactly HAART.
| References|| |
|1.||Solomon S, Kumarasamy N, Ganesh AK, Amalraj RE. Prevalence and risk factors HIV-1 and HIV-2 infection in urban and rural areas in Tamilnadu, India. Int J STD AIDS 1998;9:98-103. [PUBMED] [FULLTEXT]|
|2.||Human Immunodeficiency Virus Type 2 / Fact sheets /CDC HIV/AIDS, p. 1-5. Available from: http://www.cdc.gov/hiv/resources/factsheets/hiv2.htm. |
|3.||Marlink R, Kanki P, Thior I, Travers K, Eisen G, Siby T, et al. Reduced rate of disease development after HIV-2 infection as compared to HIV-1. Science 1994;265:1587-90. [PUBMED] [FULLTEXT]|
[Table - 1]