Indian J Sex Transm Dis Indian J Sex Transm Dis
Official Publication of the Indian Association for the Study of Sexually Transmitted Diseases
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LETTER TO EDITOR
Year : 2008  |  Volume : 29  |  Issue : 1  |  Page : 49-50
 

Resistant condyloma acuminata in HIV positive patient treated with cryotherapy once a week along with alternate day application of topical imiquimod 5% cream


Department of Dermatology, Smt. N. H. L. Munici Medical College, Vadilal Sarabhai General Hospital, Ahmedabad, Gujarat, India

Correspondence Address:
Sanjay Singrodia
Department of Dermatology, Smt. N. H. L. Munici Medical College, Vadilal Sarabhai General Hospital, Ahmedabad, Gujarat
India
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How to cite this article:
Singrodia S, Panchal M, Solanki RB, Rawal RC. Resistant condyloma acuminata in HIV positive patient treated with cryotherapy once a week along with alternate day application of topical imiquimod 5% cream. Indian J Sex Transm Dis 2008;29:49-50

How to cite this URL:
Singrodia S, Panchal M, Solanki RB, Rawal RC. Resistant condyloma acuminata in HIV positive patient treated with cryotherapy once a week along with alternate day application of topical imiquimod 5% cream. Indian J Sex Transm Dis [serial online] 2008 [cited 2019 Oct 22];29:49-50. Available from: http://www.ijstd.org/text.asp?2008/29/1/49/42721


Sir,

Condyloma Acuminata [1] is a viral sexually transmitted disease caused by human papilloma virus (HPV) type 6, 11, 16, and 18 most commonly infecting the perianal area and presenting as extensive vegetating masses mainly in diabetics, pregnant women, and immunocompromised patients.

A male patient aged 32 years presented with a chief complaint of perianal warty growth since 5 months [Figure 1]. Patient had a past history of same type of growth around the anal region two and half years back and a history of recurrent fever and cough. Surgical excision was done one year later. After the surgical excision, there was a relapse of growth for which he was treated with topical podophyllin application. [2] There was again a relapse after two months. Cryotherapy [2] was administered once a week along with alternate day topical application of imiquimod 5% cream [3] for 12 weeks. After 12 weeks of regular treatment, the size of the growth reduced to 90% of original size. After 16 weeks of regular treatment, it completely cleared [Figure 2]. On investigation, patient was HIV positive.

Condyloma Acuminata [1] in HIV positive patients is common manifestation and is very resistant to various treatment modalities. It may progress to malignancy. Treatment with topical immunomodulator application like imiquimod 5% cream [3],[4],[5] along with cryotherapy [2],[6] once a week may be effective and show promising results in resistant and relapsing cases as well as in complete elimination of the HPV virus.

 
   References Top

1.Sykes NL Jr. Condyloma acuminatum. Int J Dermatol 1995;34:297-302.  Back to cited text no. 1  [PUBMED]  
2.Congilosi SM, Madoff RD. Current therapy for recurrent and extensive anal warts. Dis Colon Rectum 1995;38:1101-7.  Back to cited text no. 2  [PUBMED]  
3.Beuter KR, Spruance SL, Hougham AJ, Fox TL, Owens ML, Douglas JM Jr. Treatment of genital warts with an immune response modifier (imiquimod). J Am Acad Dermatol 1998;38:230-9.  Back to cited text no. 3    
4.Moore RA, Edwards JE, Hopwood J, Hicks D. Imiquimod for the treatment of genital warts: A quantitative systematic review. BMC Infect Dis 2001;1:3.   Back to cited text no. 4  [PUBMED]  [FULLTEXT]
5.Edwards L, Ferenczy A, Eron L, Baker D, Owens ML, Fox TL, et al. Self-administered topical 5% imiquimod cream for external anogenial warts. Arch Dermatol 1998;134:25-30.  Back to cited text no. 5  [PUBMED]  [FULLTEXT]
6.Godley MJ, Bradbeer CS, Gellan M, Thin RN. Cryotherapy compared with trichloroacetic acid in treating genital warts. Genitourin Med 1987;63:390-2.  Back to cited text no. 6  [PUBMED]  [FULLTEXT]


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