Indian J Sex Transm Dis Indian J Sex Transm Dis
Official Publication of the Indian Association for the Study of Sexually Transmitted Diseases
Indian J Sex Transm Dis
The Journal | Search | Ahead Of Print | Current Issue | Archives | Instructions | Subscribe | Login    Users online: 932   Home Email this page Print this page Bookmark this page Decrease font size Default font size Increase font size


 
ORIGINAL ARTICLE
Year : 2009  |  Volume : 30  |  Issue : 1  |  Page : 28-30
 

Frequency of HBV, HCV and HIV infections among hospitalized injecting drug users in Kashan


Department of Infectious Diseases, Ghotb Ravand blvd, Kashan University of Medical Science, Kashan, Iran

Date of Web Publication5-Sep-2009

Correspondence Address:
Alireza Sherif
Ghotb Ravand blvd, Kashan University of Medical Science, Kashan
Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7184.55477

Rights and Permissions

 

   Abstract 

Context: Infectious diseases including HIV and viral hepatitis constitute a major health issue, with high prevalence among injecting drug users (IDUs). Aims: The present study assessed the frequency of HIV, and hepatitis B and C viruses (HBV and HCV) among 200 IDUs, hospitalized between 2001 and 2006, in Shahid Beheshti Hospital of Kashan, Iran. Setting and Design: A population-based cross-sectional study in Iran. Materials and Methods: A total of 200 subjects participated in this study. Serological markers including HBsAg, anti-HCV antibodies and HIV were assessed by ELISA method using Monobid kits made in US. Demographic data was collected by using a questionnaire, which was designed by a researcher. Statistical Analysis Used: Frequencies were determined by employing SPSS:PC version 15.0, and Chi-square and Fisher's exact tests were used to compare proportions. Results: The mean age of subjects was 36.5 ± 10.2 years. Approximately 88.5% (177 cases) were male and 11.5%. (23 cases) were female. The frequency of positive infection test results for males with respect to HBV, HCV, and HIV was 4% (8 cases), 10.5% (21 cases), and 1.5% (3 cases); and for females it was 0.5% (1 case), 1.5% (3 cases), and 0% (0 case), respectively. Conclusion: This study demonstrates that the frequency of HBV, HCV, and HIV infection in the IVD user in Kashan, Iran, is relatively high and this condition is more serious in male than female drug addicts. It is very important, especially for health providers and policy makers, to recognize the risk factors of HBV, HCV and particularly HIV infection in this area and design effective preventive programs.


Keywords: HBV, HCV, HIV, injecting drug user


How to cite this article:
Sharif M, Sherif A, Sayyah M. Frequency of HBV, HCV and HIV infections among hospitalized injecting drug users in Kashan. Indian J Sex Transm Dis 2009;30:28-30

How to cite this URL:
Sharif M, Sherif A, Sayyah M. Frequency of HBV, HCV and HIV infections among hospitalized injecting drug users in Kashan. Indian J Sex Transm Dis [serial online] 2009 [cited 2019 Nov 18];30:28-30. Available from: http://www.ijstd.org/text.asp?2009/30/1/28/55477



   Introduction Top


Infectious diseases including HIV and viral hepatitis constitute major health issues, with particularly high prevalence among injecting drug users (IDUs). Viral hepatitis is a potential major health issue that can be caused by different etiologic agents. [1] These types of infections are spread worldwide, although their prevalence varies in different regions. It is estimated that there are approximately 350 million carriers of hepatitis B virus (HBV) in the world, with one million deaths per year as a consequence of hepatitis B. [1],[2],[3] Also, more than 150,000 people are infected with hepatitis C virus (HCV) each year in the US, and approximately 20 to 30% of these patients are at risk for developing cirrhosis. [4] Blood-borne hepatitis can become a chronic infection at proportions which vary depending on the causative agent. Among adults with HBV infection, 5−10% can become chronic and a higher frequency (90%) is observed in HCV, a super infection. [4],[5],[6] Liver cirrhosis and hepatocellular carcinoma are two of the major late complications of viral hepatitis.[3],[7] HBV is associated with fulminate hepatitis in approximately 1−2% of acute cases, whereas HCV is rarely associated with this complication. [4],[5],[6] Injecting drug users (IDUs) belong to a section of population, more frequently exposed to many viral infections, including HBV, HCV, and HIV. [8] Furthermore, these subjects play a role as a reservoir and source of viral transmission in the intra- and extra-exposure categories. The prevalence of blood-borne hepatitis is usually higher among IDU than in other comparable non-IDU population strata. [9] Epidemiological data indicate that IDUs represent the largest risk group for HCV infection. [10] The aim of the present study was to assess the frequency of HBV, HCV, and HIV infections and their respective risk factors among IDUs from .


   Materials and Methods Top


IDU population and testing

The subject for this research included 200 injecting drug users hospitalized between 2001 and 2006, at Shehid Beheshti Hospital, Kashan, a city 200 km south of Tehran, Iran. The patients voluntarily participated in the study. The injecting users were hospitalized at the infection ward of the hospital. According to ethical guidelines, formal consent was obtained from each individual, who was interviewed using a standardized questionnaire including questions regarding socio-demographic status. All subjects were tested for the presence of anti-HBc, HBsAg, anti-HCV, and anti-HIV infection by drawing 5 cc of their blood samples. Serological markers including HBsAg, anti-HCV antibodies, and HIV were assessed by ELISA method using Monobid kits made in the US. Demographic data was collected by using a researcher designed questionnaire.

Statistical analysis

Following the completion of data collection for all the participants, statistical analysis were performed using the SPSS:pc version 15.0. The results of analysis are presented in [Table 1]. Tests of association between gender and affliction to infectious diseases were also performed using chi-square and Fisher's exact test (Yates corrected) and t -test for means were employed. Results were regarded at the P value set to 0.05.


   Results Top


In this research, 200 IDUs were examined. The results of analysis indicated that 177 patients were males (88.5%) and 23 were females (11.5%). The mean age of the subjects was 36.5 ± 10.2 years. The results of test analysis performed in lab revealed that the frequency of positive infection among the male with regards to HBV, HCV, and HIV was 4% (8 cases), 10.5% (21 cases), and 1.5% (3 cases); and for female it was 0.5% (1 case), 1.5% (3 cases), and 0% (0 case), respectively. These results are presented in [Table 1]. The results of demographic data analysis showed that 73% (146) individuals had under diploma degree and 27% (54) patients had higher than high school diploma; and all the HIV patients had less than diploma education. Also, 1% (2) had HBV and HCV simultaneously; whereas, none of the patient suffered from HBV, HCV, and HIV at the same time.

In addition, Chi square test was used to examine the relationship between gender and addition. The results of analysis showed that there was no significant association between these factors ( P > 0.05), nor there was any significant association between the marital status and IVD ( P > 0.05).


   Discussion Top


The present study shows a high prevalence of blood-borne viral hepatitis among IDUs from Kashan, a region of unknown endemicity for HBV infection. The frequency of HBsAg found in this study (4.5%) for men was within the range of approximately 1.30−8.69% by other researchers. [10],[11] But, this was relatively lower than those observed in areas of high endemicity, with more than 8% of HBsAg prevalence studies of IDUs in Santos, SP, Brazil, [12] and 6.5% in Kabul, Afghanistan. [13] The frequency of HCV infection for male patients in this study was 11.9%, whereas 1.3% for female subjects. However, no significant association was found between the gender and affliction to this infection. These results are similar to those reported in a study conducted in China. [14] As HBV and HCV have the same transmission routes, dual infection may occur. Patients coinfected with HBV and HCV may have more severe liver disease and high mortality rate (10%). [15],[16]

As De Jarlais [ 17] pointed, IDUs constitute an important source of viral infections and therefore can play an important role in the transmission of viruses to the general population. Hence, a public health intervention with the implementation of comprehensive prevention programs including information, face-to-face education, empowerment strategies, distribution or exchange of clean injecting equipment and distribution of condoms must be encouraged. These measures are especially relevant in developing countries such as Iran, Afghanistan, and Brazil; where Public Health programs are under budgeted and understaffed, and frequently lack expertise and political support for implementation.

 
   References Top

1.Purcell RH. The hepatitis viruses: an overview. In: Nishioka K, Suzuki H, Mishiro S and Oda T (Editors), Viral Hepatitis and Liver Disease . Springer Verlag: Tokyo, Japan; 1995.  Back to cited text no. 1    
2.Grosheide P and van Damme P. Prevention and control of hepatitis B in the community. In: Hallauer J, Kane M, McCoy E, Meleus A and Moure C (Editors), Communicable Diseases Series , 1 . World Health Organization: Geneva; 1996.   Back to cited text no. 2    
3.Hadziyannis SJ. Hepatitis delta: an overview. In: Rizzetto M, Purcell RH, Gerin JL and Verme G (Editors), Viral Hepatitis and Liver Disease . Edizioni Minerva Medica: Rome, Italy; 1997. p. 283-9.   Back to cited text no. 3    
4.Gish RG, Lau JYN. Hepatitis C virus: eight years old. Viral Hepatitis Reviews 1997;1:17-37.   Back to cited text no. 4    
5.Moyer LA, Mast EE. Hepatitis B: Virology, epidemiology, disease and prevention and an overview of viral hepatitis. Am J Prev Med 1994;10:45-55.   Back to cited text no. 5    
6.Purcell RH, Gerin JL. Hepatitis delta virus. In: Fields BN, Knipe DM, Howley PM, Chamock RM, Melnick JL, Monath TP, Roizman B and Strauss SE (Editors), Fields Virology. Vol. 2. Lippincott-Raven Publishers: Philadelphia; 1996. p. 2819-29.   Back to cited text no. 6    
7.Colombo M. Hepatocellular carcinoma: An overview. In: Rizzetto M, Purcell RH, Gerin JL and Verme G (Editors), Viral Hepatitis and Liver Disease. Edizioni Minerva Medica: Rome, Italy; 1997. p. 479-83.   Back to cited text no. 7    
8.Telles PR, Bastos FI, Guydish J, Inciardi JA, Surratt HL, Pearl M, et al . Risk behavior and HIV seroprevalence among injecting drug users in Rio de Janeiro, Brazil. AIDS 1997;11:S35-42.   Back to cited text no. 8    
9.Dan M, Rock M, Lilos P, Shany SB. Seroepidemiology of hepatitis B and hepatitis D virus infection among intravenous drug addicts in Israel. Int J Epidemiol 1993;22:140-3.   Back to cited text no. 9    
10.Massarat S, Malekzadeh R, Rezvan H. Hepatitis B in Iran. Arch Iranian Med 2000;3:192-201.  Back to cited text no. 10    
11.Farhat A, Khademi G, Mazlouman SJ. The prevalence of hepatitis B carrier state in Khorassan province of Iran. Saudi Med J 2003;24:549-51.   Back to cited text no. 11    
12.Carvalho HB, Mesquita F, Massad E, Bueno TC, Lopes GT, Ruiz MA and Burattini MN (1995). HIV and infections of similar transmission patterns in a drug injectors community of Santos, Brazil. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 1995;12:84-92.   Back to cited text no. 12    
13.Todd CS, Abed AM, Strathdee SA, Scott PT, Botros BA, Safi N, et al . HIV, hepatitis C, and hepatitis B infections and associated risk behavior in injection drug users, Kabul, Afghanistan. Emerg Infect Dis 2007;13:1327-31.   Back to cited text no. 13    
14.Xia X, Luo J, Bai J, Yu R. Epidemiology of hepatitis C virus infection among injection drug users in China: Systematic review and meta-analysis. Public Health 2008;122:990-1003.  Back to cited text no. 14    
15.Mohamed Ael S, al Karawi MA, Mesa GA. Dual infection with hepatitis C and B viruses: Clinical and histological study in Saudi patients. Hepatogastroenterology 1997;44:1404-6.  Back to cited text no. 15    
16.Perumalswami PV, Bini EJ. Epidemiology, natural history and treatment of hepatitis B virus and hepatitis C virus coinfection. Minerva Gastroenterol Dietol 2006;52:145-55.   Back to cited text no. 16    
17.De Jarlais DC, Stimson GV, Hagan H, Perlman D, Choopanya K, Bastos FI, Friedman SR. Emerging infectious diseases and the injection of illicit psychoactive drugs. Current Issues in Public Health 1996;2:130-7.   Back to cited text no. 17    



 
 
    Tables

  [Table 1]


This article has been cited by
1 Socio-Economic Status Determines Risk of Receptive Syringe Sharing Behaviors among Iranian Drug Injectors; A National Study
Shervin Assari,Khodabakhsh Ahmadi,Majid Rezazade
Frontiers in Psychiatry. 2015; 5
[Pubmed] | [DOI]
2 Norjizak injection: A critical risk for transmitting blood-borne infectious diseases
Alam Mehrjerdi, Z.
Hepatitis Monthly. 2013; 13(4)
[Pubmed]
3 Norjizak Injection: A Critical Risk for Transmitting Blood-Borne Infectious Diseases
Zahra Alam Mehrjerdi
Hepatitis Monthly. 2013; 13(4)
[Pubmed] | [DOI]
4 Frequency of HIV and HCV co-infections in chronic HBV patients referred to Taleghani Hospital, Tehran, Iran from 2006 to 2010
Tahaei, S.M.E., Mohebbi, S.R., Azimzadeh, P., Vahedi, M., Almasi, S., Romani, S., Sharifian, A., (...), Zali, M.R.
Hepatitis Monthly. 2011; 11(12): 993-996
[Pubmed]
5 Frequency of HIV and HCV Co-Infections in Chronic HBV Patients Referred to Taleghani Hospital, Tehran, Iran from 2006 to 2010
Seyed Mohammad Ebrahim Tahaei,Seyed Reza Mohebbi,Pedram Azimzadeh,Mohsen Vahedi,Shohreh Almasi,Sara Romani,Afsaneh Sharifian,Faramarz Derakhshan,Mohammad Reza Zali
Hepatitis Monthly. 2011; 11(12): 993
[Pubmed] | [DOI]
6 Seroprevalence study of hepatitis C and hepatitis B virus among hospitalized intravenous drug users in Ahvaz, Iran (2002-2006)
Alavi, S.M. and Behdad, F.
Hepatitis Monthly. 2010; 10(2): 101-104
[Pubmed]



 

Top
Print this article  Email this article
Previous article Next article

    

 
  Search
 
   Next article
   Previous article 
   Table of Contents
  
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Article in PDF (119 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  


    Abstract
    Introduction
    Materials and Me...
    Results
    Discussion
    References
    Article Tables

 Article Access Statistics
    Viewed3609    
    Printed317    
    Emailed1    
    PDF Downloaded171    
    Comments [Add]    
    Cited by others 6    

Recommend this journal