Indian J Sex Transm Dis Indian J Sex Transm Dis
Official Publication of the Indian Association for the Study of Sexually Transmitted Diseases
Indian J Sex Transm Dis
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Year : 2013  |  Volume : 34  |  Issue : 2  |  Page : 102-106

Value of human papillomavirus typing for detection of anal cytological abnormalities

1 Pathological Anatomy, Center of University Hospital of Brasilia, DF, Brazil
2 Department of Molecular Biology, Sabin Laboratory, DF, Brazil
3 Coloproctology Service of University Hospital of Brasilia, DF, Brazil

Correspondence Address:
Fabiana Pirani Carneiro
Department of Pathology of University Hospital of Brasilia, Via L2 Norte, SGAN 604/605, CEP: 70840-050, Brasília
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Source of Support: Fundação de Apoio à Pesquisa do Distrito Federal (FAP-DF) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)., Conflict of Interest: None

DOI: 10.4103/0253-7184.120540

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Purpose: The objective of this study was to evaluate anal cytology and human papillomavirus (HPV) typing in patients with human immunodeficiency virus infection. Materials and Methods: Anal samples were collected from 61 patients (44 men and 17 women) and analyzed by PapilloCheck test and conventional cytology. Results: Of all anal samples, 37.7% had cytological abnormalities, 47.54% were negative and 14.75% were unsatisfactory. High-risk HPV, multiple high-risk HPV and HPV 16 infection was detected in 91.13%, 78.26% and 47.82% of the samples with cytological abnormalities and in 47.54%, 6.89% and 3.44% of the negative samples, respectively. High-risk HPV infection was significantly more frequent in anal samples with cytological abnormalities than in negative samples (P = 0.0005, Fisher's test), particularly multiple high-risk HPV infection (P < 0.0001) and HPV 16 infection (P = 0.0002). Conclusions: High-risk HPV, multiple high-risk HPV and HPV 16 infections are significantly associated with anal cytological abnormalities. Furthermore, the frequency of HPV infection in anal cytological samples suggests that high-risk HPV detection has high sensitivity, but low specificity for detection of anal cytological abnormalities, but multiple high-risk HPV typing and HPV 16 typing have a lower sensitivity and high specificity. Results suggest that HPV typing may be useful as an adjunct to cytology to screen patients for high-resolution anoscopy and biopsy.

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