Indian J Sex Transm Dis Indian J Sex Transm Dis
Official Publication of the Indian Association for the Study of Sexually Transmitted Diseases
Indian J Sex Transm Dis
The Journal | Search | Ahead Of Print | Current Issue | Archives | Instructions | Subscribe | Login    Users online: 122   Home Email this page Print this page Bookmark this page Decrease font size Default font size Increase font size
ORIGINAL ARTICLE
Year : 2013  |  Volume : 34  |  Issue : 2  |  Page : 102-106

Value of human papillomavirus typing for detection of anal cytological abnormalities


1 Pathological Anatomy, Center of University Hospital of Brasilia, DF, Brazil
2 Department of Molecular Biology, Sabin Laboratory, DF, Brazil
3 Coloproctology Service of University Hospital of Brasilia, DF, Brazil

Correspondence Address:
Fabiana Pirani Carneiro
Department of Pathology of University Hospital of Brasilia, Via L2 Norte, SGAN 604/605, CEP: 70840-050, Brasília
Brazil
Login to access the Email id

Source of Support: Fundação de Apoio à Pesquisa do Distrito Federal (FAP-DF) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)., Conflict of Interest: None


DOI: 10.4103/0253-7184.120540

Rights and Permissions

Purpose: The objective of this study was to evaluate anal cytology and human papillomavirus (HPV) typing in patients with human immunodeficiency virus infection. Materials and Methods: Anal samples were collected from 61 patients (44 men and 17 women) and analyzed by PapilloCheck test and conventional cytology. Results: Of all anal samples, 37.7% had cytological abnormalities, 47.54% were negative and 14.75% were unsatisfactory. High-risk HPV, multiple high-risk HPV and HPV 16 infection was detected in 91.13%, 78.26% and 47.82% of the samples with cytological abnormalities and in 47.54%, 6.89% and 3.44% of the negative samples, respectively. High-risk HPV infection was significantly more frequent in anal samples with cytological abnormalities than in negative samples (P = 0.0005, Fisher's test), particularly multiple high-risk HPV infection (P < 0.0001) and HPV 16 infection (P = 0.0002). Conclusions: High-risk HPV, multiple high-risk HPV and HPV 16 infections are significantly associated with anal cytological abnormalities. Furthermore, the frequency of HPV infection in anal cytological samples suggests that high-risk HPV detection has high sensitivity, but low specificity for detection of anal cytological abnormalities, but multiple high-risk HPV typing and HPV 16 typing have a lower sensitivity and high specificity. Results suggest that HPV typing may be useful as an adjunct to cytology to screen patients for high-resolution anoscopy and biopsy.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1782    
    Printed46    
    Emailed0    
    PDF Downloaded39    
    Comments [Add]    
    Cited by others 1    

Recommend this journal