Indian J Sex Transm Dis Indian J Sex Transm Dis
Official Publication of the Indian Association for the Study of Sexually Transmitted Diseases
Indian J Sex Transm Dis
The Journal | Search | Ahead Of Print | Current Issue | Archives | Instructions | Subscribe | Login    Users online: 268   Home Email this page Print this page Bookmark this page Decrease font size Default font size Increase font size
Year : 2014  |  Volume : 35  |  Issue : 2  |  Page : 100-103

Metabolic abnormalities in human immunodeficiency virus patients with protease inhibitor-based therapy

1 Department of Medicine, Regional Institute of Medical Sciences, Imphal, Manipur, India
2 Department of Biochemistry, Regional Institute of Medical Sciences, Imphal, Manipur, India
3 Department of Biostatistics, Regional Institute of Medical Sciences, Imphal, Manipur, India

Correspondence Address:
Bhimo Thongam
Department of Medicine, Regional Institute of Medical Sciences, Imphal - 795 004. Manipur
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0253-7184.142399

Rights and Permissions

Context: Several studies have reported metabolic abnormalities in patients taking protease inhibitor (PI) based therapy from several parts of the world. But there is no prospective study in India after switching from PI sparing regimen to PI based regimen. Aims: To assess whether North-East Indian Human Immunodeficiency Virus (HIV) patients also develop similar metabolic abnormalities to PI. Settings and Design: This prospective study was conducted in Anti-retroviral therapy (ART) Centre of Excellence, at a tertiary care Medical Institute. Materials and Methods: Fifty-five patients taking PI based ART were taken for the study. These patients were started on Ritonavir based therapy, after treatment with first line drugs had failed according to National AIDS Control Organization (NACO) guidelines 2008. Glucose and lipid profiles were evaluated. American Diabetes Association (ADA) and NCEP ATP III criteria were used to categorize glucose and lipid abnormalities. International Diabetes Federation (IDF) 2006 cut-off was used for waist circumference and blood pressure. Statistical Analysis Used: Paired t-test was done whenever applicable. Results: There was a significant increase in waist circumference after 6 months of 2 nd line ART from 78.0 cm to 80.2 cm (P value < 0.001). There was significant increase in both systolic and diastolic blood pressure after 6 months. In 29.8% of patients blood pressure rose to hypertensive level after 6 months. Total cholesterol, triglyceride and low density lipoprotein cholesterol also rose significantly after 6 months but not high density lipoprotein cholesterol. Conclusions: Our study showed that North-Eastern Indian patients also develop metabolic abnormalities to protease inhibitors similar to people of other races.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded99    
    Comments [Add]    

Recommend this journal