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Official Publication of the Indian Association for the Study of Sexually Transmitted Diseases
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CASE REPORT
Year : 2014  |  Volume : 35  |  Issue : 2  |  Page : 135-137
 

Genital donovanosis with malignant transformation: An interesting case report


Department of Dermatology, Mamata Medical College and Hospital, Khammam, Telangana, India

Date of Web Publication9-Oct-2014

Correspondence Address:
A Swetha Chowdary
Department of Dermatology, Mamata General Hospital, Khammam, Telangana
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7184.142409

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   Abstract 

Donovanosis is a chronic indolent sexually transmitted granulomatous ulceration of genito-inguinal region, caused by Calymmatobacterium granulomatis. It became uncommon due to indiscriminate use of broad spectrum antibiotics. In recent years, much interest is being focused on this condition because genital ulcers facilitate HIV infection. We report an interesting episode of genital donovanosis complicated with squamous cell carcinoma in a middle aged female for its rarity and clinical interest.


Keywords: Donovan bodies, donovanosis, malignant transformation


How to cite this article:
Sri K N, Chowdary A S, Reddy B. Genital donovanosis with malignant transformation: An interesting case report. Indian J Sex Transm Dis 2014;35:135-7

How to cite this URL:
Sri K N, Chowdary A S, Reddy B. Genital donovanosis with malignant transformation: An interesting case report. Indian J Sex Transm Dis [serial online] 2014 [cited 2019 Aug 17];35:135-7. Available from: http://www.ijstd.org/text.asp?2014/35/2/135/142409



   Introduction Top


Donovanosis is a sexually transmitted infection presenting with fleshy exuberant granulomatous ulceration. Though donovanosis is considered a sexually transmitted infection, there is possibility that the lesions are not always sexually transmitted, but through fecal contamination and autoinoculation. [1] Malignancy, though a rare complication, should be suspected in patients not responding to antibiotic treatment. We are reporting an interesting case of genital donovanosis with malignant transformation for its rarity and clinical interest.


   Case report Top


A 50-year-old female presented to our outpatient clinic, with a painless ulcerative growth that bleeds on touch over the left vulva of 5 years duration. Initially, her problem started as a painless small skin lesion over the left labia and gradually progressed to ulceration to involve the entire vulva. She is married since 30 years and denied history of extramarital sexual exposure. Her husband is healthy with no history of genital ulcers.

Clinical examination of the patient revealed a granulomatous ulcer measuring 7 cm × 5 cm extending from the clitoris to fourchette involving the entire left labia [Figure 1]. Ulcer was nontender, bleeding on touch with everted edges. Bilateral, nontender, firm, discrete inguinal lymphadenopathy was present. Rest of the skin and systemic examination revealed no other abnormality.
Figure 1: Clinical photograph of donovanosis patient showing ulcerogranulomatous lesion over left labia

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Tissue smear from the edge of the ulcer showed pink ovoid bodies containing dark blue nuclei with bipolar condensation lying within and also outside of large monocytes [Figure 2]. A clinical diagnosis of donovanosis was made based on the smear report. Serology for HIV, hepatitis and Venereal Disease Research Laboratory were nonreactive.
Figure 2: Tissue smear showing Donovan bodies

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Patient was prescribed capsule doxycycline 100 mg bid for 2 weeks. This did not show any clinical improvement in her condition. Hence, a fine-needle aspiration cytology (FNAC) of the inguinal lymphnode was carried out along with a biopsy from the edge of the ulcer. Both these reports demonstrated features suggestive of squamous cell carcinoma with oval cells containing large hyperchromatic nuclei, abundant cytoplasm, high N/C ratio and keratin pearl formation [Figure 3] and [Figure 4]. She was explained about the disease and was referred to MNJ Institute of Oncology Regional Cancer Centre, Hyderabad for further management, where the diagnosis of squamous cell carcinoma was confirmed, and subsequently she has undergone radical vulvectomy with bilateral inguinal lymphnode block dissection [Figure 5].
Figure 3: Fine-needle aspiration cytology of inguinal lymphnode showing oval cells containing large hyperchromatic nuclei, abundant cytoplasm and high N/C ratio suggestive of squamous cell carcinoma

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Figure 4: Photomicrograph of biopsy from the ulcer of donovanosis patient showing histopathologic features of squamous cell carcinoma with oval cells with large hyperchromatic nuclei, abundant cytoplasm with high N/C ratio and keratin pearl formation (H and E, ×40)

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Figure 5: Postoperative picture following vulvectomy

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   Discussion Top


Donovanosis was first described in 1882 by McLeod [2] and the etiologic agent (Donovan bodies) was demonstrated in 1905 by Major Charles Donovan in the tissue smears of an oral granuloma patient from Madras General Hospital. [3] It is a mildly contagious, gradually progressive, often sexually transmitted, granulomatous ulceration of the genito-inguinal area caused by Gram-negative bacillus Calymmatobacterium granulomatis.

The disease usually manifests initially with a small papule or nodule which gets eroded to form characteristic clinical lesions namely (a) ulcerogranulomatous or fleshy exuberant, (b) necrotic, (c) hypertrophic or verrucous, and (d) sclerotic or cicatricial type. [1],[4] Although it is generally considered as a sexually transmitted infection (STI), lesions may occur through fecal contamination and autoinoculation. [5]

Largest epidemic occurred in Papua New Guinea between 1922 and 1952. However, according to recent studies by WHO it has become rare now. [1] A sentinel surveillance conducted in 2004 combining all the studies in South Africa from 1980 to 2000 revealed the proportion of genital ulcer disease attributable to granuloma inguinale to be close to 1%. [6]

In various STI clinics, the prevalence ranged from 0.013% in Tezpur to 8.2% in Pondicherry and 10% in Mumbai. In Chandigarh, the prevalence declined from 6.3% in 1977-1985 to 0.5% in 1995-1996. In Delhi, it increased from 0.25% in 1955-61 to 1.4% in 1989-95 and then declined to 0.48% in 1995-99 [7] Two epidemics of donovanosis occurred in Delhi, in 1983 and 1985, when the reported incidences were 6.38% and 8.33%, respectively. [7]

In recent years, the incidence of donovanosis has decreased to the extent that the cases are almost sporadic even in the areas where it was once prevalent in significant numbers due to the efforts to curtail genital ulcers as a public health issue with syndromic management of sexually transmitted diseases by broad spectrum antibiotics coupled with usage of condoms as a precautionary measure to prevent HIV epidemic transmission. [8]

Our patient manifested with ulcerogranulomatous lesions. Based on the characteristic morphology of her genital ulcers and presence of typical Donovan bodies in the tissue smears, she was diagnosed as a case of donovanosis, and administered antibiotic treatment. Lack of therapeutic benefit to this coupled with chronicity of her ulcer made us suspect malignant transformation, which was confirmed with subsequent FNAC of inguinal lymph node and histopathologic examination of the ulcer.

Most frequent complications of donovanosis include pseudoelephantiasis as a consequence of lymphatic obstruction, mutilations and obstruction of the vaginal orifice due to destruction of tissues and consequent fibrosis. However, the most important complication in long standing cases is the malignant transformation of the ulcers as evidenced in our patient. This feature has been observed in about 0.25% of the patients in Rajam and Rangaiah series [9] and also in a few isolated case reports. [10],[11],[12] It is important to note that lack of response to conventional treatment, especially in long standing lesions of donovanosis should alert the suspicion of malignant transformation.

 
   References Top

1.
O′Farrell N. Donovanosis. Sex Transm Infect 2002;78:452-7.  Back to cited text no. 1
    
2.
McLeod K. Precis of operations performed in the wards of the first surgeon, Medical College Hospital, during the year 1881. Indian Med Gaz 1882;111:113-23.  Back to cited text no. 2
    
3.
Donovan C. Medical cases from Madras General Hospital: Ulcerating granuloma of the pudenda. Indian Med Gaz 1905;40:414.  Back to cited text no. 3
    
4.
Hart G. Donovanosis. Clin Infect Dis 1997;25:24-30.  Back to cited text no. 4
    
5.
Goldberg J. Studies on granuloma inguinale. V. Isolation of a bacterium resembling Donovania granulomatis from the faeces of a patient with granuloma inguinale. Br J Vener Dis 1962;38:99-102.  Back to cited text no. 5
    
6.
Johnson LF, Coetzee DJ, Dorrington RE. Sentinel surveillance of sexually transmitted infections in South Africa: A review. Sex Transm Infect 2005;81:287-93.  Back to cited text no. 6
    
7.
Sharma VK, Khandpur S. Changing patterns of sexually transmitted infections in India. Natl Med J India 2004;17:310-9.  Back to cited text no. 7
    
8.
O′Farrell N. Donovanosis. In: Gupta S, Kumar B, editors. Sexually Transmitted Infections. 2 nd ed. India  Elsevier; 2012. p. 533.  Back to cited text no. 8
    
9.
Rajam RV, Rangaiah PN. Donovanosis. Monogr Ser World Health Organ 1954;24:1-72.  Back to cited text no. 9
    
10.
Thappa DM, Senthikumar M, Laxmisha C. Malignant transformation of donovanosis. Indian J Sex Transm Dis 2004;125:77.  Back to cited text no. 10
    
11.
Sardana K, Garg VK, Arora P, Khurana N. Malignant transformation of donovanosis (granuloma inguinale) in a HIV-positive patient. Dermatol Online J 2008 15;14:8.  Back to cited text no. 11
    
12.
Agrawal M, Arora SK, Agarwal A. A forgotten disease reminds itself with a rare complication. Indian J Dermatol 2011;56:430-1.  Back to cited text no. 12
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    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5]



 

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