Indian Journal of Sexually Transmitted Diseases and AIDS
REVIEW ARTICLE
Year
: 2016  |  Volume : 37  |  Issue : 2  |  Page : 115--122

Recapitulation of acquired immuno deficiency syndrome associated Kaposi's sarcoma


Balaji Govindan 
 Department of STD, Government Mohan Kumaramangalam Medical College, Salem, Tamil Nadu, India

Correspondence Address:
Balaji Govindan
Department of STD, Government Mohan Kumaramangalam Medical College, Salem - 636 001, Tamil Nadu
India

Acquired immuno deficiency syndrome (AIDS) associated Kaposi's sarcoma (KS) is one of the clinical forms of KS. KS is caused by human herpes viruses 8 or KS associated herpes virus (KSHV). In India, till now, only 16 cases of AIDS associated KS was reported. Of all the clinical forms of KS, AIDS associated KS is distinct in many ways viz.; cutaneous manifestations commonly affects face and trunk rather than lower limbs, more mucosal lesions, rapidly progressive, and early systemic involvement. When human immunodeficiency virus (HIV) is co-infected with KSHV, in addition to the other pathogenic factors for the development of KS, HIV Tat protein promotes the proliferation of cytokine-activated endothelial cells and stimulates KS. Moreover, actions of HIV Tat lead to the aggressive course of KS in patients with AIDS, compared with the more confined behavior of KS in HIV-negative persons. Similarly, latency-associated nuclear antigen of KSHV would enhance HIV replication by activating the long terminal repeats of HIV-1 through its association with Tat. Effective antiretroviral treatment in AIDS associated KS results in reduction of the incidence of AIDS-related KS and regression of the existing lesions. Early diagnosis and treatment of AIDS associated KS would definitely increase the life span and quality of the patients.


How to cite this article:
Govindan B. Recapitulation of acquired immuno deficiency syndrome associated Kaposi's sarcoma.Indian J Sex Transm Dis 2016;37:115-122


How to cite this URL:
Govindan B. Recapitulation of acquired immuno deficiency syndrome associated Kaposi's sarcoma. Indian J Sex Transm Dis [serial online] 2016 [cited 2017 Sep 25 ];37:115-122
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