Indian Journal of Sexually Transmitted Diseases and AIDS
ORIGINAL ARTICLE
Year
: 2019  |  Volume : 40  |  Issue : 1  |  Page : 42--45

Clinical, immunological, and virological outcomes in HIV patients on raltegravir-based salvage therapy


Rajesh Deshwal, Sumit Arora 
 Apex Immunodeficiency Centre, Department of Medicine, Base Hospital, Delhi Cantt, New Delhi, India

Correspondence Address:
Dr. Sumit Arora
Department of Medicine, Base Hospital Delhi Cantt, - 110 010, New Delhi
India

Objectives: The objective of the study is to assess the clinical, immunological, and virological outcomes in treatment-experienced HIV patients on raltegravir (RAL)-based salvage therapy. Methods: This was a retrospective, observational study of patients with suspected second-line antiretroviral therapy failure who were followed up for at least 6 months, from January 2013 to January 2017, after switching to salvage regimen. A total of 20 patients who fulfilled the inclusion criteria and who had RAL-based salvage therapy were assessed for clinical, immunological and virological response. The data were picked up from the electronic database of the center and analyzed. Results: Age, sex, date of initial diagnosis, date, and type of first line and second line regimens were documented, CD4 count, and plasma viral load at the time of initiation and after 3 and 6 months were recorded. Undetectable viral load was documented in all patients at 6 months. No noticeable adverse effects were noted. Conclusion: This study clearly shows that RAL containing regimens have a high degree of effectiveness in treatment-experienced patients and show effective and durable suppression of viral load with low adverse effect rates and reliable long-term safety.


How to cite this article:
Deshwal R, Arora S. Clinical, immunological, and virological outcomes in HIV patients on raltegravir-based salvage therapy.Indian J Sex Transm Dis 2019;40:42-45


How to cite this URL:
Deshwal R, Arora S. Clinical, immunological, and virological outcomes in HIV patients on raltegravir-based salvage therapy. Indian J Sex Transm Dis [serial online] 2019 [cited 2019 Oct 22 ];40:42-45
Available from: http://www.ijstd.org/article.asp?issn=2589-0557;year=2019;volume=40;issue=1;spage=42;epage=45;aulast=Deshwal;type=0