Indian J Sex Transm Dis Indian J Sex Transm Dis
Official Publication of the Indian Association for the Study of Sexually Transmitted Diseases
Indian J Sex Transm Dis
The Journal | Search | Ahead Of Print | Current Issue | Archives | Instructions | Subscribe | Login    Users online: 1319   Home Email this page Print this page Bookmark this page Decrease font size Default font size Increase font size
ORIGINAL ARTICLE
Year : 2011  |  Volume : 32  |  Issue : 1  |  Page : 23-29

Determinants of rapid progression to immunodeficiency syndrome among people infected with human immunodeficiency virus, Kerala, India


1 Department of Community Medicine, Government Medical College, Thiruvananthapuram, Kerala, India
2 Sree Gokulam Medical College, Venjarammoodu, Thiruvananthapuram, Kerala, India

Correspondence Address:
T S Anish
Department of Community Medicine, Government Medical College, Thiruvananthapuram, Kerala
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7184.81250

Rights and Permissions

Context: Human Immunodeficiency Virus (HIV) infection progresses in almost all infected persons to Acquired Immunodeficiency Syndrome (AIDS). The aim of the study was to find out the determinants of rapid progression of immunodeficiency among people infected with HIV in Thiruvananthapuram district of Kerala, India. Settings and Design: The study design used was case control. The setting of the study was antiretroviral treatment (ART) centre of Government Medical College and the self-help group of HIV patients located at Thiruvananthapuram, Kerala. Materials and Methods: Cases were people having any one or more of the AIDS defining clinical conditions within 3 years from the diagnosis of HIV infection. Controls were people diagnosed as having HIV at least 3 years ago and with no AIDS-defining clinical conditions till the date of the study. Sample size was 149 with a control case ratio of 1.5:1. Statistical analysis used: Mean (standard deviation) and proportions were used to describe the data. Chi-square test and t test were done to test the hypotheses. Binary logistic technique was used to find out the predictors of the outcome. Results: A regression (Binary Logistic) model was used to predict the progression. Fungal infection of nail [adjusted Odds Ratio (OR), 6.4 (1.4, 28.9)] and oral candidiasis [adjusted OR, 2.6 (1.1, 6.4)] were the clinical conditions significantly associated with rapid progression. The significant social factors included non-exposure to professional counseling [adjusted OR, 7.1 (2.0, 24.5)] and the feeling of being stigmatized - felt as preoccupation with thoughts that they are gossiped about and the increase in visitors to "check them out" [adjusted OR, 26.1 (4.9, 138.4)]. The protective nutritional factors in the model were frequent consumption of legumes [adjusted OR, 0.12 (0.04, 0.36)], eggs [adjusted OR, 0.29 (0.09, 0.93)], and plenty of oral fluids [adjusted OR, 0.18 (0.07, 0.47)]. Conclusions: An approach incorporating the clinical, social, and nutritional factors may retard the progression of HIV infection.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed4301    
    Printed219    
    Emailed0    
    PDF Downloaded106    
    Comments [Add]    
    Cited by others 1    

Recommend this journal