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No clinical predictors of intraepithelial neoplasia in HIV-positive patients with external condilomata acuminata
Paula Giacaman1, María José Martínez2, Jonas Chnaiderman2, Sandra Ampuero2, Ester Santander1, Claudia Ramis3, Ivo Sazunic4, María Luisa Garmendia5, Orietta Gómez4
1 Dermatology Department, Hospital San José, Chile
2 Virology Program, ICBM, Faculty of Medicine, University of Chile, Chile
3 Pathology Service, Hospital San José, Chile
4 Dermatology Department, Hospital Clínico Universidad de Chile, Chile
5 Epidemiology Division, Public Health School, Faculty of Medicine, University of Chile, Santiago, Chile
Correspondence Address:
María José Martínez
Virology Program, Faculty of Medicine, University of Chile, Independencia 1027, Independencia. 6530499, Santiago
Chile
 Source of Support: O.A.I.C. Hospital J.J. Aguirre and Virology
Program, I.C.B.M., Faculty of Medicine, University of Chile, Conflict of Interest: None  | Check |
DOI: 10.4103/0253-7184.81251
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To identify clinical parameters in association with human papilloma virus (HPV) genotypes and histopathology diagnosis in HIV-positive patients with external condylomata acuminata (ECA), 400 Chilean HIV-positive patients were included in the study. Forty-seven patients presented ECA. Clinical parameters and socio demographic data were recorded. Histopathology study and HPV linear array genotyping assay were performed. Intraepithelial neoplasia (IEN) grade 2 or 3 was found in 8.5% of patients, associated to HPV-16. Patients were mainly single, MSM, with history of sexually transmitted disease (STD), multiple sexual partners, receiving antiretroviral therapy and with recurrent lesions. All ECA were mainly perianal, grey or pink colored, exophytic with less than two years evolution. No clinical parameter could predict the development of high grade IEN in HIV patients with ECA. It seems necessary to perform biopsy and genotype all HIV positive patients with ECA. |
