Indian J Sex Transm Dis Indian J Sex Transm Dis
Official Publication of the Indian Association for the Study of Sexually Transmitted Diseases
Indian J Sex Transm Dis
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CASE REPORT
Year : 2011  |  Volume : 32  |  Issue : 1  |  Page : 47-49

Prozone phenomenon in secondary syphilis


Department of Dermatology, J. J. M. Medical College, Davangere, Karnataka, India

Correspondence Address:
Ruchi Sidana
J.J.M. Medical College, Department of Dermatology, Davangere 577 004, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7184.81256

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Prozone phenomenon is a false negative response resulting from high antibody titer which interferes with formation of antigen- antibody lattice, necessary to visualize a positive flocculation test. We present a case of secondary syphilis who presented to us with features of contact irritant dermatitis. She initially tested non- reactive for VDRL testing but tested positive with higher dilution. The prozone phenomenon is attaining importance because of increasing prevalence of Acquired immune deficiency syndrome. So one needs to be familiar with the occurrence of prozone phenomenon.


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