Indian J Sex Transm Dis Indian J Sex Transm Dis
Official Publication of the Indian Association for the Study of Sexually Transmitted Diseases
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LETTERS TO EDITOR
Year : 2020  |  Volume : 41  |  Issue : 1  |  Page : 129
 

CD4+ count after arabinoxylan supplementation: An observation


1 Vitallife Wellness Center, Bumrungrad International Hospital, Bangkok, Thailand
2 Department of Community Medicine, Dr DY Patil University, Pune, India

Date of Submission28-Oct-2016
Date of Acceptance05-Dec-2019
Date of Web Publication18-Jun-2020

Correspondence Address:
Dr. Kamon Chaiyasit
Vitallife Wellness Center, Bumrungrad International Hospital, Bangkhae, Bangkok
Thailand
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijstd.IJSTD_93_16

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How to cite this article:
Chaiyasit K, Wiwanitkit V. CD4+ count after arabinoxylan supplementation: An observation. Indian J Sex Transm Dis 2020;41:129

How to cite this URL:
Chaiyasit K, Wiwanitkit V. CD4+ count after arabinoxylan supplementation: An observation. Indian J Sex Transm Dis [serial online] 2020 [cited 2020 Nov 28];41:129. Available from: https://www.ijstd.org/text.asp?2020/41/1/129/287019


Sir,

The immunomodulation due to the food supplementation is a very interesting issue. In complementary medicine, several food supplementations are mentioned for ability to promote immunity. Here, the authors report on the observation on CD4+ count after getting arabinoxylan supplementation. The patient is a 22-year-old Thai male with known anti-HIV seropositive status. At presentation, his viral load was equal to 4320 copies/ml and CD4+ =27.88%, CD4+ count = 499 cell/mm3. This patient denied antiretroviral therapy and sought for alternative nutritional management at the nutritional management clinic. The patient got arabinoxylan 4 g/day. There is no other concomitant treatment. One month later, his viral load was equal to 38,630 copies/ml and CD4+ =34%, CD4+ count = 715 cell/mm3. Arabinoxylan is a starch product that is mentioned for its clinical usefulness. In pig, arabinoxylan is proved for promoting intestinal barrier function.[1] In mice, it is proved that arabinoxylan helps promote natural killer cells.[2] It is also mentioned for ability to promote human phagocytic cells.[3] In human subjects, the recent report by Cholujova et al. showed that arabinoxylan was effective for modulating innate immunity in multiple myeloma patients.[4] Here, the authors show additional evidence that arabinoxylan can help promote CD4+. It could be seen that CD4+ count rises after getting arabinoxylan. Nevertheless, there is no effect on viral load. Arabinoxylan might be a good nutritional supplementation for patients with anti-HIV seropositive in view of promoting CD4+.

Consent

The authors obtained written consent from the patient for reporting of the case.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient has given his consent for his images and other clinical information to be reported in the journal. The patient understands that name and initials will not be published and due efforts will be made to conceal identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Chen H, Wang W, Degroote J, Possemiers S, Chen D, De Smet S, et al. Arabinoxylan in wheat is more responsible than cellulose for promoting intestinal barrier function in weaned male piglets. J Nutr 2015;145:51-8.  Back to cited text no. 1
    
2.
Ghoneum M, Abedi S. Enhancement of natural killer cell activity of aged mice by modified arabinoxylan rice bran (MGN-3/Biobran). J Pharm Pharmacol 2004;56:1581-8.  Back to cited text no. 2
    
3.
Ghoneum M, Matsuura M, Gollapudi S. Modified arabinoxylan rice bran (MGN3/Biobran) enhances intracellular killing of microbes by human phagocytic cells in vitro. Int J Immunopathol Pharmacol 2008;21:87-95.  Back to cited text no. 3
    
4.
Cholujova D, Jakubikova J, Czako B, Martisova M, Hunakova L, Duraj J, et al. MGN-3 arabinoxylan rice bran modulates innate immunity in multiple myeloma patients. Cancer Immunol Immunother 2013;62:437-45.  Back to cited text no. 4
    




 

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