LETTER TO EDITOR
|Year : 2022 | Volume
| Issue : 2 | Page : 231
CD4+ count change after COVID-19 vaccination: Observation on HIV-infected vaccine recipient
Rujittika Mungmunpuntipantip1, Sim Sai Tin2, Viroj Wiwanitkit3
1 Private Academic Consultant, Bangkok, Thailand
2 Shantou Medical Center, Shantou, China
3 Department of Community Medicine, Dr. D.Y. Patil University, Pune, India
|Date of Submission||16-Sep-2021|
|Date of Decision||17-Sep-2021|
|Date of Acceptance||18-Sep-2021|
|Date of Web Publication||17-Nov-2022|
Dr. Rujittika Mungmunpuntipantip
Private Academic Consultant, Bangkok
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Mungmunpuntipantip R, Tin SS, Wiwanitkit V. CD4+ count change after COVID-19 vaccination: Observation on HIV-infected vaccine recipient. Indian J Sex Transm Dis 2022;43:231
|How to cite this URL:|
Mungmunpuntipantip R, Tin SS, Wiwanitkit V. CD4+ count change after COVID-19 vaccination: Observation on HIV-infected vaccine recipient. Indian J Sex Transm Dis [serial online] 2022 [cited 2023 May 31];43:231. Available from: https://ijstd.org/text.asp?2022/43/2/231/361335
COVID-19 vaccination is the hope for containment on COVID-19 outbreak. The effect of new COVID-19 vaccine is the present interesting issue. Regarding HIV-infected case, there are limited data on the effect of HIV vaccination. Similar antibody responses against SARS-CoV-2 in HIV uninfected and infected vaccine recipients were recently reported by Snyman et al. Levy et al. also confirmed for good immunogenicity and safety of COVID-19 vaccine for HIV-infected persons.
Here, the authors share our preliminary observation of CD4+ change after COVID-19 vaccination on 25 HIV-infected vaccine recipients (15 males and 10 females, age 35–48 years old). All cases are HIV-infected patients who have regular following up at HIV Clinic. All receive standard antiretroviral medication. All received COVID-19 viral vaccine, according to local vaccination policies. The authors retrospectively analyzed the clinical record data on CD4+ count of the patients, measures within 2 months before vaccination and the CD+ count at 1 month after vaccination. All CD4+ counts are performed by standard laboratory technique and according to routine clinical practice for the management of HIV infected cases. All investigations are routine care service and all patients gave informed consent for CD4+ count investigation. The protocol of this work is approved by the local ethical committee (S34R/2021, April 26, 2021). Based on retrospective analysis, average CD4+ counts significantly increases after COVID-19 vaccination [Table 1]. This preliminary observation is interesting and there should be further study on clinical association between COVID-19 vaccination and CD4+ count.
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| References|| |
Snyman J, Hwa SH, Krause R, Muema D, Reddy T, Ganga Y, et al.
Similar antibody responses against SARS-CoV-2 in HIV uninfected and infected individuals on antiretroviral therapy during the first South African infection wave. Clin Infect Dis 2022;75:e249-e56.
Levy I, Wieder-Finesod A, Litchevsky V, Biber A, Indenbaum V, Olmer L, et al.
Immunogenicity and safety of the BNT162b2 mRNA COVID-19 vaccine in people living with HIV-1. Clin Microbiol Infect 2021;27:1851-5.